Interactive Electrophysiology Imaging (EPS)

This project is focused on enabling interactive and intuitive presentation of anatomically registered electrophysiology data to cardiac clinicians for improved interventional treatment of rhythm disturbances, such as persistent atrial fibrillation (PeAF), which is a known risk of stroke and contributes to mortality in congestive heart failure. Current techniques for identifying the functional and anatomic substrates that sustain PeAF are ineffective. We propose to address this using real-time electrophysiological mapping of the atrial chambers.

A diagram showing electro-anatomic mapping of atrial fibrillation.

The objectives are: (i) to project potentials acquired with novel intra-atrial multi-electrode catheters onto the inner atrial surfaces in real-time; (ii) to develop new signal analysis techniques for characterising spatio-temporal waveform complexity in PeAF; and (iii) to validate these methods using large-animal experiments. These pathways will enable high technology solutions to be implemented in the clinical workflow for routine evaluation of patients with CVD.

Back to Flagship 2: Cardiovascular diagnostics and therapeutics.